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KMID : 0191119980130030269
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Journal of Korean Medical Science
1998 Volume.13 No. 3 p.269 ~ p.274
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Clinicopathologic study of basaloid squamous carcinoma of the upper aerodigestive tract
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Kim JY
Cho KJ/Lee SS/Khang SK/Shim YS
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Abstract
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The clinicopathologic and immunohistochemical characteristics of nine cases of basaloid squamous carcinoma
(BSC) of the upper aerodigestive tract are reported, along with the results of an in situ hybridization for
human papilloma virus (HPV) DNA. The cases were selected through a review of 237 head and neck carcinomas,
and were located in the supraglottic larynx (5), hypopharynx (2), and the base of tongue (2). The patients
were 7 males and 2 females with the mean age of 62. BSCs were histologically characterized by lobules and
nests of basaloid cells with scanty cytoplasm, comedonecrosis and adenoid features, and by concomitant
presence of squamous cell carcinoma. Immunohistochemically, all BSCs showed positivity for high molecular
weight cytokeratin (HMW CK) with heterogeneous or diffuse staining pattern, but lacked reactivity for
neuroendocrine markers and bcl-2 oncoprotein. No HPV DNA was detected in BSCs. This study reaffirms that
BSC is a rare carcinoma with a peculiar topographic distribution and distinct pathologic features.
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KEYWORD
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